Working collaboratively to provide creative solutions

to protein challenges in drug discovery

Proteins on the Edge: A Membrane Spotlight

This month we're focusing on one of our areas of specialisation; membrane proteins. We have a dedicated team of membrane protein experts, proficient in both production and structural determination. This month we've highlighted recent work on these tricky drug targets 

Expressing and Purifying the 5-HT_2AR GPCR for cryo-EM Structural Studies

PIPS PhD Student Ben Nash discusses his work at Peak Proteins during a 3-month placement, optimising expression of the GPCR 5-HT_2AR for Cryo-EM.

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Using the BacMam System to Generate a Membrane Protein

 In this case study, we discuss our recent work establishing an alternative platform for mammalian membrane protein expression.

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Introduction to Detergents for Membrane Protein Solubilisation

Detergents are frequently used to aid membrane solubilisation - in this blog we discuss why detergents are used and compare the merits of some of the  detergents we use here.

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More Membrane Protein content

IMPROvER the Integral Membrane Protein Stability Selector

Working with GPCRs

'SMALPed' GPCRs

FSEC of membrane proteins

Membrane protein webcast