Working collaboratively to provide creative solutions

to protein challenges in drug discovery

Determining the Cryo-EM Structure of the 5-HT_2A receptor with Serotonin Bound

Learn about how we determined the active state structure of the 5-HT_2A receptor with the natural ligand serotonin bound using cryo-EM

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A Comparison of the Structural Techniques used at Sygnature Discovery: X-ray Crystallography, NMR and Cryo-EM

We are fortunate to offer three different routes towards structure determination. In this blog we discuss their individual merits, what each workflow looks like, and how they fit into drug discovery.

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10 Years of Protein Science

This week we celebrated the 10th anniversary of Peak Proteins (Now part of Sygnature Discovery).
Read more about our conception and our journey to becoming part of Sygnature Discovery. Who are we? What makes us tick? and what are 'Protein Whisperers'!

PIPS Placement Working on Targeted Protein Degradation

PIPSs Student Scott Allen reflects on his 3-month placement at Peak Proteins (part of Sygnature Discovery), using Fida and SEC-MALs to study Targeted Protein Degradation.

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