Working collaboratively to provide creative solutions
to protein challenges in drug discovery
Production of Active Cereblon and Analysis by SPR
Cereblon enables efficient protein degradation in proximity-based therapeutics like PROTACs. We demonstrate our capability to produce high quality Cereblon for drug discovery.
At Peak Proteins we put a great deal of effort into thinking about construct design. Here we discuss a recent case where we used AlphaFold as an aid to construct design.
Papain digestion can be used to generate Fab fragments from full-length antibodies. This case study highlights the problems that can occur when using this method and why we generally prefer to produce Fabs by recombinant expression.
