Working collaboratively to provide creative solutions
to protein challenges in drug discovery
Intrinsically Disordered Proteins as Drug Discovery Targets
In the latest blog post, we dive deep into the fascinating world of Intrinsically Disordered Proteins (IDPs) and their emerging role as drug discovery targets.
In this case study, we demonstrate the production and SPR characterisation of the VHL/EloB/EloC (VCB) complex, a critical ubiquitin ligase substrate receptor used in targeted protein degradation (TPD) approaches.
O-linked glycans are less well-studied and understood than their N-linked counterparts but can dramatically impact protein function. We discuss the role of these modifications and our experience with identifying them.
We were delighted last month to host Year 12 work experience students who learned about what we do here and got hands-on experience pipetting, setting up cultures, and growing crystals.
